ArticleFrontiers in microbiology2026
Gut microbiota analysis in diabetic mice with periodontitis.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aimed to investigate the composition and alterations of gut microbiota in mice with comorbid diabetes and periodontitis. Materials and methods: A total of 40 six-week-old male db/db and db/m mice were divided into four groups ( Results: Compared with the db/m group, the db/m + PD group showed no significant differences in fasting blood glucose and the area under the oral glucose tolerance test curve (AUC). In contrast, compared with the db/db group, the db/db + PD group exhibited significantly elevated fasting blood glucose and the area under the oral glucose tolerance test curve. Relative to the db/m group, the db/m + PD group demonstrated a significant increase in C-reactive protein (CRP). Compared with the db/db group, the db/db + PD group showed high density lipoprotein cholesterol (HDL-C) significantly reduced and Interleukin-10 (IL-10) significantly increased. Pancreatic histology revealed marked islet morphological alterations in both db/db and db/db + PD groups. Significant alveolar bone loss was observed in db/m + PD and db/db + PD groups, with pronounced inflammatory infiltration on periodontal histology, most severe in db/db + PD group. Alpha and beta diversity analyses indicated notable changes in microbial richness and community structure across the four groups. The gut microbiota dysbiosis index was significantly higher in the three experimental groups than in the db/m group. Intergroup comparisons revealed extensive compositional differences at both phylum and genus levels. Conclusion: Our results showed that the degree of alveolar bone resorption and the microbial dysbiosis index (MDI) in the db/db + PD group were significantly higher than those in the db/m, db/m + PD, and db/db groups. Meanwhile, the destruction of pancreatic
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