ArticleClinical kidney journal2026
Similar predictive performance and clinical utility of the Kidney Failure Risk Equation using EKFC or CKD-EPI estimated glomerular filtration rate.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: International guidelines recommend the Kidney Failure Risk Equation (KFRE), which includes estimated glomerular filtration rate (eGFR), to guide nephrology referral and preparation for kidney replacement therapy in chronic kidney disease (CKD). The European Kidney Function Consortium (EKFC) eGFR equations are increasingly recognized as alternatives to CKD-EPI, but their impact on KFRE predictive performance and clinical utility is unknown. Methods: We identified adults with same-day creatinine and cystatin C measurements and an albuminuria assessment in Stockholm between 2011 and 2021. We evaluated 2- and 5-year 4-variable KFRE performance using CKD-EPI or EKFC eGFR equations based on creatinine (eGFR Results: Among 27 125 participants (median age 75 years; 45% women), KFRE discrimination was consistently excellent across all equations, filtration markers, and prediction horizons (AUC 0.95-0.97). For eGFR Conclusions: In this North-European health system study, estimating eGFR with EKFC or CKD-EPI equations does not materially alter the predictive performance or clinical utility of the KFRE.
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