ArticleNPJ dementia2026
Brain age gradients as intermediate phenotypes linking plasma p-tau217 to cognition in community-dwelling older adults.
Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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8 authors.
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Abstract
Deep learning-based brain age models quantify regional deviations from normative aging and may capture structural changes relevant to dementia risk. Plasma phosphorylated tau-217 (p-tau217) is a scalable Alzheimer's disease biomarker, but its relationship to brain aging and cognition in cognitively unimpaired adults is unclear. In this cross-sectional study, we tested whether brain age patterns serve as indirect pathways linking plasma p-tau217 to cognition in the Aging Brain Cohort (ABC). Neuroimaging data from 518 adults (mean age = 43.7 years, 70.8% female) were analyzed using a validated deep learning brain age model, and decomposed via exploratory factor analysis into six gradients: frontal, dorsal, ventral, left frontotemporal, right frontotemporoparietal, and bilateral parietal. In a parallel mediation model including all six gradients as simultaneous mediators in adults aged ≥60 years (
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