Assembly and Stability of Lipid-Coated Silver Nanoparticles: A Combined UV-VIS / Multispectral iSCAT Study.

Baichuan Cheng, Saatwik Suman, Ritesh Bag, Tianhong Ouyang, Björn M Reinhard

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Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Baichuan ChengDepartment of Material Engineering, Boston University, Boston, MA 02215, United States.

Saatwik SumanDepartment of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, United States.

Ritesh BagDepartment of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, United States.

Tianhong OuyangDepartment of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, United States.

Björn M ReinhardDepartment of Chemistry and The Photonics Center, Boston University, Boston, MA 02215, United States.

Funding

Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor Signal Transduction Pathway Using Plasmon CouplingR01CA138509 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Bjoern Markus Reinhard · 2009 to 2026

$5.9M

NCI NIH HHS R01 CA138509

6 · The paper itself

Abstract

Although silver nanoparticles (AgNPs) have superb optical properties, insufficient chemical stability and inertness precludes their application in many biosensing applications. Lipid-coating is a potential strategy to enhance the stability of AgNPs in complex chemical environments, but the lipid assembly depends on several parameters that require optimization. Stability assays are key for performance optimization, but conventional ensemble-based strategies may obscure an underlying heterogeneity of these hybrid nanostructures. In this work, we employ multispectral interferometric scattering (iSCAT) microscopy to characterize the oxidative etching of lipid-coated silver NPs (L-AgNPs) at the single-particle level. By monitoring the real-time etching of individual NPs, we resolve a distinct bimodal behavior that is undetectable

Indexed as

iSCAT MicroscopyKineticsLipid CoatingMembrane IntegrityOxidative EtchingPhase TransitionSilver NanoparticlesSurface Passivation

Identifiers

PMID42422483

DOI10.1021/acs.jpcc.6c01408

PMCPMC13344197

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