Evidence map›Paper›PMID 42422410›Full record

ArticleCJC pediatric and congenital heart disease2026

Exercise Capacity, Endothelial Function, Muscle Mass, and Strength in Pediatric Patients With Fontan Circulation.

Mavis C Lui, Latha Palaniappan, Mary B Leonard, Jin Long, Joseph Dehoney, John P Cooke, Inger Olson, Tulsi R Damase, Sharon Chen, Jonathan Myers and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC pediatric and congenital heart disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04195451 (RE-ENERGIZE FONTAN), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04195451 nacompletednot on this map

RE-ENERGIZE FONTAN: A RandomizEd Exercise INtERvention DesiGned to MaximIZE Fitness in Pediatric FONTAN Patients

TypeinterventionalSponsorStanford UniversityRan2020 to 2026Enrolled150ConditionsSingle-ventricleArmsLive-Video-Supervised Exercise Intervention, Usual Care then Live-Video Supervised Exercise Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mavis C LuiDepartment of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, California, USA.
Latha PalaniappanDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Mary B LeonardDepartment of Pediatrics, Division of Pediatric Nephrology, Stanford University School of Medicine, Stanford, California, USA.
Jin LongDepartment of Pediatrics, Division of Pediatric Nephrology, Stanford University School of Medicine, Stanford, California, USA.
Joseph DehoneyDepartment of Computer Science, Stanford University School of Engineering, Stanford California, USA.
John P CookeDepartment of Cardiovascular Sciences, Houston Methodist Hospital & Research Institute, Houston, Texas, USA.
Inger OlsonDepartment of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, California, USA.
Tulsi R DamaseDepartment of Cardiovascular Sciences, Houston Methodist Hospital & Research Institute, Houston, Texas, USA.
Sharon ChenDepartment of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, California, USA.
Jonathan MyersDepartment of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Daniel BernsteinDepartment of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, California, USA.
Seda TierneyDepartment of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fontan circulation carries high morbidity and mortality, driven in part by impaired exercise capacity, muscle deficits, and endothelial dysfunction. In a pediatric cohort with Fontan circulation, we examined associations between exercise capacity, endothelial function, and muscle parameters before enrollment in a randomized exercise intervention. Methods: Patients aged 8-19 years who have Fontan circulation were included. Exclusion criteria included New York Heart Association class IV, active illness, protein-losing enteropathy, pacemaker, or cognitive delay. Assessments included cardiopulmonary exercise testing (peak VO Results: Among 137 participants (median age 12.7 years; 53% single right ventricle), median time since Fontan was 8.6 years. Peak VO Conclusion: In youth with Fontan circulation, lower aerobic capacity was associated with lower endothelial function, leg lean mass, strength, and mobility, underscoring the interdependence of cardiovascular, vascular, and musculoskeletal health. Clinical Trial Registration: NCT04195451.

Indexed as

endothelial functionexerciseFontansingle-ventricle

Identifiers

PMID42422410
PMCPMC13343420

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.