Evidence map›Paper›PMID 42422367›Full record

ArticleNeuro-oncology advances

Implanted dynamic electric field therapy for glioblastoma: preclinical safety and efficacy of intratumoral modulation therapy.

Erin Iredale, Niveen Fulcher, Amir H Akbarzadeh, Abdulla Elsaleh, Elizabeth Fenton, Cleusa De Oliveira, John A Ronald, John J Kelly, Susanne Schmid, Terry M Peters and 2 more

Abstract read
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Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erin IredaleDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0003-3551-4813
Niveen FulcherDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Amir H AkbarzadehDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Abdulla ElsalehDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Elizabeth FentonDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Cleusa De OliveiraDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
John A RonaldDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
John J KellyDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Susanne SchmidDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0001-5366-8061
Terry M PetersDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Eugene WongDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Matthew O HebbDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Electric field-based approaches show therapeutic impact against glioblastoma, with 1-3 V/cm often cited as the range of threshold intensities for antitumor effects. However, the field amplitudes required for maximal impact and strategies needed to achieve them in the brain remain poorly defined. This study aimed to evaluate the safety, electrical integrity, field distribution, and efficacy of a novel implanted Intratumoral Modulation Therapy (IMT) delivering spatiotemporally dynamic electric fields in an aggressive Methods: IMT was evaluated in the rat F98 glioblastoma model using implanted intracerebral electrodes delivering continuous 200 kHz dynamic electric fields for 7 days. Electric field distributions were assessed with finite-element simulations and direct electrical measurements. Tumor response was quantified via bioluminescence and magnetic resonance imaging. Tissue impedance, delivered voltage, and Results: IMT produced no neurological adverse effects or imaging evidence of brain injury. Tumor progression was significantly suppressed, with 8-fold reduction in bioluminescence progression and 5-fold reduction in magnetic resonance imaging-measured tumor volume growth. Broad tumor and peritumoral regions received fields of >1 V/cm, while localized intratumoral regions reached 5-8 V/cm, confirmed by simulation and direct measurement. Mean brain temperature within the central field increased by 1°C. Conclusions: Multi-electrode IMT generated broad, spatiotemporally dynamic electric fields that safely exceeded putative amplitude thresholds and significantly attenuated glioblastoma growth

Indexed as

brain cancerelectrotherapyglioblastomaintratumoral modulation therapy

Identifiers

PMID42422367
PMCPMC13345699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.