ArticleKidney diseases (Basel, Switzerland)
Interstitial Fibrosis and Tubular Atrophy as a Predictor of Renal Outcomes in Patients with Malignant Hypertension-Related Thrombotic Microangiopathy: A Multicentric Cohort Study.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Interstitial fibrosis and tubular atrophy (IFTA) are common pathological findings in patients with malignant hypertension (mHTN)-related thrombotic microangiopathy (TMA), but their predictive value for renal outcomes in this population remains unclear. Methods: This study included patients with mHTN-related TMA confirmed by renal biopsy, admitted to seven different Chinese hospitals from January 2008 to October 2024. Patients were stratified into mild/moderate, severe, and extremely severe IFTA groups based on renal biopsy findings. The primary outcome was renal replacement therapy (RRT) dependence during follow-up, while the secondary outcome was renal function recovery. Results: A total of 465 patients (median age: 35 years, 87.74% male) were included in this study. During a median follow-up of 24 months, RRT dependence occurred in 182 patients and renal function recovery occurred in 226 patients. Kaplan-Meier analysis showed higher RRT risk with more severe IFTA. Cox regression models showed that severe and extremely severe IFTA groups had hazard ratios of 2.29 (95% CI: 1.59-3.28) and 8.00 (95% CI: 5.36-11.95) for RRT dependence compared to mild/moderate IFTA group (both Conclusion: IFTA may serve as a valuable and independent predictor of renal outcomes in patients with mHTN-related TMA, highlighting its importance for clinical decision-making.
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