ArticleOsteoarthritis imaging2026
Baseline 3D joint space width on weight-bearing CT in comparison with 2D JSW
Article in Osteoarthritis imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Objective: This study evaluated the predictive validity of baseline 3D joint space width (3D-JSW) measured using weight-bearing computed tomography (WBCT) versus 2D-JSW on radiographs for predicting knee structural worsening over 24 months, assessed by radiographs and MRI. Design: A prospective observational study using data from the Multicenter Osteoarthritis Study (MOST) included 425 knees. Baseline 3D-JSW was assessed using WBCT acquired in a standing fixed-flexion position, and 2D-JSW was assessed from standing fixed-flexion posteroanterior radiographs. Outcomes included 24-month changes in tibiofemoral Osteoarthritis Research Society International (OARSI) joint space narrowing (JSN) grade and MRI Osteoarthritis Knee Score Cartilage Morphology (MOAKS-CM). Predictive validity was evaluated using logistic regression and comparison of areas under ROC curves. Results: The study population (N=302) had a mean age of 63.2 years (standard deviation 8.9) and BMI of 28.2 kg/m Conclusions: 3D-JSW did not show superior predictive validity over 2D-JSW in predicting knee structural worsening over 24 months in a cohort predominatly without radiographic knee OA. WBCT remains a promising imaging modality for osteoarthritis assessment. Further studies are needed to determine its role as a diagnostic tool.
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