ReviewFrontiers in neuroscience2026
Transcutaneous auricular vagus nerve stimulation: mechanisms, applications, and research progress.
Review in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review systematically examines the mechanisms of action, optimization of stimulation parameters and targets, and the research progress in the application of taVNS for neurological disorders and systemic conditions. Rather than merely cataloging existing findings, this review critically synthesizes recent advances with a focused emphasis on two core aspects: (1) the mechanistic convergence and divergence among neuroimaging, autonomic, and molecular pathways underlying taVNS effects; and (2) the methodological challenges and biomarker-driven strategies for optimizing stimulation parameters and personalizing treatment. By prioritizing these key directions over exhaustive enumeration of clinical applications, this review aims to provide a conceptually structured framework that distinguishes genuine progress from descriptive accumulation. Moreover, compared with previously published reviews on similar topics, the present work offers a distinctive contribution by integrating multi-modal mechanistic evidence into a testable model of taVNS action and critically evaluating the translational gap between parametric optimization in research settings and standardized clinical implementation. Furthermore, it provides an outlook on future research directions and technological developments, aiming to offer a comprehensive theoretical framework to inform both clinical translation and foundational research in this rapidly evolving field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.