SynthesisFrontiers in pediatrics2025
Efficacy and safety of phototherapy for jaundice in full-term newborns: a meta-analysis.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The efficacy and safety of phototherapy in the treatment of full-term neonatal jaundice were meta-analyzed, and the advantages of phototherapy were summarized. Methods: PubMed, Embase, Cochrane Library, and Web of Science databases were searched using subject + free words for the subject words "phototherapy," "jaundice," and "full-term newborn," and the search time was limited from 1 January 2000 to 25 April 2024, and the search language was unlimited. According to the inclusion criteria and exclusion criteria, two researchers independently conducted a three-level screening of the retrieved literature to obtain the included literature. Collected and compared information included in the literature. Review Manager 5.3 was used to plot bias plots, forest plots, and funnel plots. Statistical analyses were performed using IBM SPSS Statistics 26 and Stata 17 software. Results: We obtained a total of 486 literature entries, of which 17 were included in the systematic review. The meta-analysis included 647 full-term neonates from 14 studies with complete serum total bilirubin (STB) data before and after phototherapy. The pooled mean reduction in STB was 5.43 mg/dL (95% CI: 5.30-5.56). Conclusion: Proper phototherapy can significantly reduce the level of STB and eliminate the symptoms of jaundice in full-term neonates. Light-emitting diode phototherapy devices demonstrated higher efficacy compared with fluorescent tube systems. The treatment is safe with minimal adverse effects. Systematic Review Registration: PROSPERO.
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