Evidence map›Paper›PMID 42422205›Full record

ArticleFrontiers in neurology

Intra-cardiac thrombus detection by electrocardiogram-gated cardiac computed tomography in hyperacute ischemic stroke.

Daniel S Green, Timmy Pham, Dennis J Cordato, Longting Lin, Daniel Akrawi, Callan Gavaghan, Chilan Nguyen, Aaron Gaekwad, Alan McDougall, Carlos Garcia-Esperon and 4 more

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Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Daniel S GreenSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Timmy PhamIngham Institute for Applied Medical Research, Liverpool, NSW, Australia.
Dennis J CordatoSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Longting LinSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Daniel AkrawiSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Callan GavaghanCardiology Department, Queen Elizabeth II Jubilee Hospital, Coopers Plains, QLD, Australia.
Chilan NguyenSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Aaron GaekwadIngham Institute for Applied Medical Research, Liverpool, NSW, Australia.
Alan McDougallSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Carlos Garcia-EsperonDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
Anthony KaplanDepartment of Radiology, Liverpool Hospital, Liverpool, NSW, Australia.
Christopher BlairSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Melissa LeungSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.
Mark W ParsonsSouth Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Traditional workup with transthoracic echocardiogram (TTE) has limited yield in the diagnosis of suspected cardioembolic stroke. The current study aimed to determine the diagnostic yield of hyperacute electrocardiogram (ECG)-gated cardiac computed tomography (CT) in comparison with TTE in the detection of intra-cardiac thrombus amongst patients with ischemic stroke within an ethnically and socioeconomically diverse population. Methods: A prospective observational analysis was undertaken of patients who had undergone cardiac CT with prospective ECG-gating as part of a hyperacute stroke imaging protocol at a single comprehensive stroke centre in Sydney, Australia between November 2022 and December 2024. Data related to demographics, clinical assessment, treatment and follow-up functional status were collected in addition to high-risk sources of cardio-aortic stroke. Results: A total of 117 patients underwent imaging with ECG-gated cardiac CT as part of their hyperacute stroke assessment. Of 69 (59%) patients with a final diagnosis of ischemic stroke, intra-cardiac thrombus was identified on cardiac CT in 18 patients (26%). Intra-cardiac thrombus was associated with a higher prevalence of premorbid hypertension (94% vs. 67%; Conclusion: ECG-gated cardiac CT identified intra-cardiac thrombus in 26% of patients who had a final diagnosis of ischemic stroke. The diagnostic yield of intra-cardiac thrombus detection was substantially higher with cardiac CT compared to TTE. Cardiac CT should be considered as part of hyperacute stroke imaging protocols. The unadjusted analysis on functional outcomes is hypothesis generating, limited by imprecision from a small sample size; further investigation requires a larger cohort with multivariable adjustment. Further studies in the hyperacute setting are required to explore benefits in different populations and with alternative imaging acquisition protocols.

Indexed as

acutecardiac CTechocardiogramgatedischemic strokethrombusTTE

Identifiers

PMID42422205
PMCPMC13345591

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.