ArticleFrontiers in cardiovascular medicine2026
Investigating association of triglycerides with hemodynamic parameters in patients with Low cardiovascular risk using 4D flow MRI.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cardiovascular disease (CVD) remains a global health challenge, with hypertriglyceridemia as a key risk factor. The relationship between triglycerides (TG) and carotid hemodynamics in low-risk populations is unclear. Materials and methods: This prospective study enrolled 180 participants aged 55 years or younger with low cardiovascular risk. Participants were divided into three groups based on TG levels: normal TG (<1.7 mmol/L), elevated TG (1.7-5.64 mmol/L), and severely elevated TG (≥5.65 mmol/L). 4D Flow MRI data were acquired using a 3 T MRI scanner, and hemodynamic parameters were measured. Statistical analysis included the Mann-Whitney Results: A total of 106 participants (mean age 37.05 ± 8.17 years, 62 males) were included. Significant differences in WSS-related parameters, particularly WSSmax and WSSmean, were observed across TG groups. In the RICA-1 segment, for normal TG, WSSmax (0.29 ± 0.10 Pa) and WSSmean (0.20 ± 0.06 Pa) were similar to those in the elevated TG group (WSSmax: 0.29 ± 0.10 Pa, WSSmean: 0.20 ± 0.06 Pa). In the severely elevated TG group, WSSmax (0.44 ± 0.14 Pa) and WSSmean (0.28 ± 0.08 Pa) were significantly higher than in the other groups ( Conclusion: Our study demonstrates that TG levels are independently associated with carotid WSS parameters after comprehensive covariate adjustment, with the most pronounced changes in the ICA-1 region among individuals with severely elevated TG. Clinical Trial Registration: https://www.chictr.org.cn/showprojEN.html?proj=224462, ChiCTR2400082465.
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