Evidence map›Paper›PMID 42422171›Full record

ArticleJournal of pharmaceutical analysis2026

Menaquinone-7 alleviates mitochondrial dysfunction and senescence in senile osteoporosis by targeting the PINK1-mediated mitophagy via PXR/ERK/CREB signaling pathway.

Yu Xu, Wencan Zhang, Wenpeng Xu, Shangzhi Li, Dingxin Zhang, Xiangyu Lin, Jincheng Liu, Qingyang Fu, Peijie Hu, Haipeng Si

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu XuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Wencan ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Wenpeng XuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Shangzhi LiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Dingxin ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Xiangyu LinDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Jincheng LiuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Qingyang FuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.
Peijie HuDepartment of Medical Experimental Center, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, 266035, China.
Haipeng SiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current therapeutic strategies for senile osteoporosis inadequately address its low-turnover pathology driven by mitochondrial dysfunction and cellular senescence. This study identifies menaquinone-7 (MK-7), a vitamin K

Indexed as

Cellular senescenceMenaquinone-7 (MK-7)Mitochondrial homeostasisMitophagyPXR/ERK/CREB signalingSenile osteoporosis

Identifiers

PMID42422171
PMCPMC13342968

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.