Evidence map›Paper›PMID 42422167›Full record

ArticleFrontiers in bioengineering and biotechnology2026

ESWT attenuates compressive stress-induced cartilaginous endplate degeneration via modulation of the

Pan Xiang, Junjun Hou, Chao Yang, Ting Liang, Wenbin Cai, Fanlei Yang, Jing Yang, Hao Xu, Zongping Luo, Yanjun Che

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In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pan Xiang *Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Junjun Hou *Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Chao Yang *Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ting LiangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Wenbin CaiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Fanlei YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jing YangDepartment of Clinical Nutrition, The First Affiliated Hospital of Soochow University, Suzhou, China.
Hao XuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zongping LuoDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yanjun CheOrthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cartilaginous endplate (CEP) degeneration is a critical contributor to intervertebral disc degeneration (IVDD) and is frequently induced by sustained compressive stress. Extracorporeal Shockwave Therapy (ESWT) has shown therapeutic potential in promoting disc repair; however, the underlying molecular mechanisms remain unclear. This study aimed to investigate the role of sclerostin (SOST) and Wnt/β-catenin signaling pathway in compression-induced CEP degeneration and to explore the protective effects of ESWT. Methods: Results: Conclusion: ESWT attenuates mechanical loading-induced CEP degeneration by upregulating SOST expression, which

Indexed as

cartilaginous endplateextracorporeal shockwave therapyintervertebral disc degenerationmechanical stimulationSOSTWnt/β-catenin

Identifiers

PMID42422167
PMCPMC13341607

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.