ArticleFrontiers in allergy2026
Panallergen sensitization in children with eosinophilic esophagitis: a pilot study.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background: Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder associated with atopic comorbidities and may be considered a late manifestation of the atopic march. This study aimed to evaluate the prevalence of atopic comorbidities, sensitization to food allergens and panallergens in pediatric EoE patients, and to explore the potential association between panallergen sensitization and response to treatment. Methods: We conducted a single-center observational study on pediatric EoE patients, followed at Vittore Buzzi Children's Hospital in Milan. Clinical, endoscopic, and histological data, together with sensitization profiles to food allergens and panallergens [profilins, PR-10 proteins, and lipid transfer proteins (LTPs)] were collected. Patients were classified into two groups according to their response to PPI therapy. Results: Twenty-four patients (median age 11.5 years, IQR 9-13; 23 males) were enrolled. 79% (19/24) had a family history of atopy and 19/24 (79%) had allergic comorbidities. Sensitization to food allergens was observed in 17/24 (71%); panallergen sensitization was detected in 15/24 patients (63%). Conclusions: This study is the first to address panallergen sensitization in a pediatric cohort of EoE patients. Our findings suggest that panallergen sensitization might be associated with response to PPI. However, these preliminary findings require confirmation in larger, powered studies.
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