ArticleCase reports in gastroenterology
Targeted Ileal Bile Acid Transporter Inhibition as Rescue Therapy for Tirzepatide-Induced Severe Constipation: A Case Report.
Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Constipation is a common, dose-dependent adverse effect of incretin-based anti-obesity therapies that affects patient adherence and may necessitate discontinuation, resulting in loss of metabolic benefits and weight regain. Elobixibat, an ileal bile acid transporter (IBAT) inhibitor, may offer a targeted alternative when conventional laxatives fail. Case Presentation: A 56-year-old woman with obesity (95 kg; BMI 38.5 kg/m Conclusion: Elobixibat provided effective relief, enabling the continuation of tirzepatide therapy. Therefore, a prospective evaluation is recommended. IBAT inhibition may represent a mechanism-based strategy to overcome the specific motility deficits induced by incretin therapy.
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