Evidence map›Paper›PMID 42421951›Full record

ArticleFrontiers in immunology2026

Mucosal-associated invariant T cells recognize a tumor-derived metabolite in the DNA synthesis pathway.

Yanqi Xue, Yuka Yamada, Rikako Suzuki, Brenda Luong, Shotaro Fujii, Keisuke Nakata, Masatomo Takahashi, Yoshihiro Izumi, Chihiro Fukui, Ryosuke Takasaki and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yanqi XueDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yuka YamadaDepartment of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Rikako SuzukiDepartment of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Brenda LuongSchool of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.
Shotaro FujiiDepartment of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Keisuke NakataDivision of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Masatomo TakahashiDivision of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Yoshihiro IzumiDivision of Metabolomics, Medical Research Center for High Depth Omics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Chihiro FukuiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryosuke TakasakiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Francois LegouxINSERM ERL1305, CNRS UMR6290, Institut de Génétique et Développement de Rennes, Université de Rennes, Rennes, France.
Shinsuke InukiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Daisuke MotookaNGS core facility, Bioinformatics Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Emi ItoDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Bridget L StockerSchool of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.
Mattie S M TimmerSchool of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand.
Takashi ShimizuJoint Faculty of Veterinary Medicine, Laboratory of Veterinary Public Health, Yamaguchi University, Yamaguchi, Japan.
Yasumasa MatsuokaAdvanced Technology Institute, Yamaguchi University, Yamaguchi, Japan.
Jun'ichi ManoScience Research Center, Organization for Research Initiatives, Yamaguchi University, Yamaguchi, Japan.
Koji TamadaDepartment of Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Makoto Furutani-SeikiSystems Biochemistry in Pathology and Regeneration, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Kei SakamotoDepartment of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Koh-Hei SonodaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Olivier LantzInstitut Curie, Paris Sciences et Lettres Université, Inserm U932, Immunity and Cancer, Paris, France.
Sho YamasakiDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Kensuke ShibataDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells recognize metabolite-derived ligands, but the identity of such ligands in the context of cancer remains poorly defined. Herein, we demonstrate that the tumor-derived metabolite 5-formyl tetrahydrofolate (5-formyl THF), which is an intermediate of the folate metabolism pathway, induces T cell receptor (TCR)-dependent activation of mouse mucosal-associated invariant T (MAIT) cells. The activity was weaker than that of a potent MAIT cell agonist 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU).

Indexed as

DNAMucosal-Associated Invariant T CellsNeoplasmsAnimalsHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellRibitolUracil5-(2-oxopropylideneamino)-6-d-ribitylaminouracilDNAReceptors, Antigen, T-CellRibitolUracilcancerDNA synthesisligandmetaboliteT cells

Identifiers

PMID42421951
PMCPMC13342176

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.