ReviewFrontiers in immunology2026
Macrophage-mediated nutrient recycling: evolutionary insights into the metabolic role of professional phagocytes.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Removal of senescent and damaged cells is fundamental for tissue homeostasis. While macrophage recognition and clearance of apoptotic cells are well characterized, the ultimate fate of the digested material remains poorly understood. Here, we explore current knowledge on the fate of engulfed material and examine how the metabolic nature of engulfed cargo shapes downstream signaling and phagocyte polarization. We also discuss emerging evidence that macrophages act as metabolic hubs, recycling and supplying nutrients to surrounding tissues. Drawing on studies in invertebrate phagocytes, we explore the evolutionary origins of this "nurturing" function and highlight its conservation in mammals, emphasizing its physiological relevance and potential contributions to metabolic disease.
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