Degalactosylated whey protein increases α-Klotho concentrations in the plasma and kidney in mice.

Toshio Inui, Namiko Kawamura, Masahiro Yamamura, Rikako Yamamura, Noriko Satoh-Asahara, Yoshihiro Ogawa, Goro Katsuura

Abstract read

In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

7 authors.

Toshio InuiSaisei Pharma, Moriguchi, Japan.

Namiko KawamuraDepartment of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Masahiro YamamuraOsaka Medical and Pharmaceutical University, Takatsuki, Japan.

Rikako YamamuraOsaka Medical and Pharmaceutical University, Takatsuki, Japan.

Noriko Satoh-AsaharaDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, Japan.

Yoshihiro OgawaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Goro KatsuuraSaisei Pharma, Moriguchi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the acceleration of global population aging, maintaining healthy longevity in an aging society become an important concern. This study examined whether D-WP influences key factors of a healthy lifespan, such as α-Klotho, fibroblast growth factor-23 (FGF-23), and sirtuin 1 (SIRT1), in mice. Mice who received oral D-WP for 8 days exhibited significantly increased plasma α-Klotho concentrations. On the other hand, plasma concentrations of FGF-23 and SIRT1 were not changed by oral intake of D-WP. Moreover, kidney α-Klotho protein concentrations were also significantly increased by oral intake of D-WP for 8 days. Oral intake of intact whey protein did not induce the same effects as D-WP. These findings suggest that D-WP may have a potency to increase plasma Klotho levels.

Indexed as

degalactosylated whey proteinkidneymiceplasmaα-Klotho

Identifiers

PMID42421928

DOI10.3389/fnut.2026.1839336

PMCPMC13343231

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.