ArticleFrontiers in nutrition2026
Exploring the bioavailability and bioactivity of thiamine versus allithiamine: studies in
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Thiamine (vitamin B Methods: Here, we conducted complementary studies in Results: In flies, thiamine deficiency caused developmental arrest at the first-instar larval stage, whereas supplementation with thiamine or allithiamine fully restored normal development. Notably, HPLC analysis revealed slightly higher tissue thiamine levels following allithiamine supplementation. In thiamine-depleted mice, supplementation with either thiamine or allithiamine resulted in similarly elevated whole blood thiamine levels and increased phosphorylated pyruvate dehydrogenase E1 subunit alpha (pPDHA1) to total PDHA1 ratios. Mitochondrial oxidative phosphorylation (OXPHOS) related protein levels remained largely unchanged, except for moderate increases in ATP synthase F1 subunit alpha (ATP5A). Likewise, only minor effects on mRNA levels of thiamine-related genes were observed following supplementation with either vitamer. Conclusion: Together, these findings provide the first direct
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.