Evidence map›Paper›PMID 42421854›Full record

ArticleFrontiers in chemistry2026

Linking phytochemistry to bioactivity:

Fatima Zahra Ayyad, Mouad Lahyaoui, Mohammed Al-Zharani, Chaimae Ibbur, Mohamed Radi, Aicha Benouahi, Morad Kaddouri, Aziz Drioiche, Fahd A Nasr, Ashraf Ahmed Qurtam and 2 more

Abstract read
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In one paragraph

Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fatima Zahra AyyadResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Mouad LahyaouiLaboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, USMBA, Fez, Morocco.
Mohammed Al-ZharaniBiology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Chaimae IbburResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Mohamed RadiResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Aicha BenouahiResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Morad KaddouriLaboratory of the Engineering and Applied Technologies, Higher School of Technology, Sultan Moulay Slimane University, Beni Mellal, Morocco.
Aziz DrioicheResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.
Fahd A NasrBiology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Ashraf Ahmed QurtamBiology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Ahde El ImacheLaboratory of Innovative Technologies, Process Engineering Department, Higher School of Technology Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Touriya ZairResearch Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences, Moulay Ismaïl University, Meknes, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study investigated the phytochemical composition and biological activities of the aqueous root extract of Methods: Phenolic compounds were extracted by decoction and quantified as total polyphenols, flavonoids, and condensed tannins. The chemical profile of the extract was characterized using HPLC/UV-ESI-MS. Antioxidant activity was evaluated using total antioxidant capacity (TAC), DPPH radical scavenging, and ferric reducing antioxidant power (FRAP) assays, while antimicrobial activity was assessed against selected bacterial and fungal strains. Acute toxicity and antihyperglycemic effects were investigated Results: The extract contained 40.58 ± 1.01 mg GAE/g DE, 9.43 ± 0.81 mg QE/g DE, and 11.96 ± 0.45 mg CE/g DE of total polyphenols, flavonoids, and condensed tannins, respectively. HPLC/UV-ESI-MS revealed the presence of ruberythric acid, galiosin, rubiadin, salvianolic acid C, and pseudopurpurin glucoside as major compounds. The extract exhibited antioxidant activity (IC Discussion: These findings highlight the significant antioxidant, antimicrobial, and antihyperglycemic potential of the extract.

Indexed as

antihyperglycemicantimicrobialantioxidantin silicoRubia tinctorumtoxicity

Identifiers

PMID42421854
PMCPMC13341306

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.