ArticleAlzheimer's & dementia (New York, N. Y.)
Identifying populations with faster cognitive decline using blood-based biomarkers.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
18 authors.
Funding
Abstract
introductionIdentifying individuals who undergo cognitive decline is vital to the success of prevention trials that aim to slow cognitive decline. Yet, the benefits of using blood-based biomarkers of neurodegeneration, as well as amyloid and tau, to enrich population-based prevention trials have not been quantified.
methodsThe association of thresholds of Quanterix single molecule array (SiMoA) assays with subsequent change in cognition was estimated in the Atherosclerosis Risk in Communities cohort (
resultsElevated plasma biomarker levels identified dementia-free older adults with faster cognitive decline. By selecting participants with Quanterix SiMoA measurements of neurofilament light > 30.65 pg/mL, the sample size needed to detect a 33% reduction in cognitive decline in a clinical trial decreased by 57%. DISCUSSION: Clinical trials can use plasma biomarkers as a screening tool to increase statistical power.
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