ReviewFrontiers in dental medicine2026
Allergenic and cytotoxic potential of (meth)acrylate monomers in dental materials: a narrative review.
Review in Frontiers in dental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This narrative review synthesizes current evidence on the allergenic and cytotoxic potential of (meth)acrylate monomers. Residual monomers act as haptens, triggering type IV (delayed-type) hypersensitivity reactions in both patients and dental professionals. Exposure occurs through dermal contact, oral mucosa, ocular tissues, and inhalation of nanoparticles generated during grinding and polishing. Standard dental gloves provide limited chemical protection. Cross-sensitization among structurally related monomers is common, and previous sensitization through non-dental sources such as nail products or industrial adhesives may predispose individuals to reactions from dental materials. The rapid adoption of additive manufacturing introduces additional concerns, as 3D-printed resins demonstrate significant variability in polymerization quality depending on post-processing protocols, and standardized guidelines remain lacking. Protective strategies should follow a hierarchy of controls approach, prioritizing safer monomer formulations, engineering controls, and no-touch techniques over personal protective equipment alone. Enhanced awareness, comprehensive allergy histories, and the development of low-allergenicity alternatives are essential to mitigate risks as (meth)acrylate use continues to expand.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.