Evidence map›Paper›PMID 42421775›Full record

ArticleCell biomaterials2026

Cerenkov radiation modulates the extracellular matrix for improved pancreatic cancer chemotherapy.

Weiwei Su, Han Wang, Shuai Zhao, Tao Wang, Jessica C Hsu, Xiuru Ji, Shuping Li, Changjing Zuo, Weibo Cai, Dalong Ni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weiwei SuDepartment of Radiology, Naval Medical Center, Shanghai, China.
Han WangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuai ZhaoDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Tao WangDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Jessica C HsuDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Xiuru JiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shuping LiDepartment of Radiology, Naval Medical Center, Shanghai, China.
Changjing ZuoDepartment of Nuclear Medicine, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.
Weibo CaiDepartments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Dalong NiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
NCI NIH HHS P30 CA014520NCI NIH HHS T32 CA009206
6 · The paper itself

Abstract

Abundant cancer-associated fibroblasts (CAFs) in pancreatic tumors cause robust interstitial fibrosis and abnormal vascular structure, hindering the delivery and effectiveness of small-molecule therapeutics, leading to poor clinical outcomes. We developed a strategy to modulate the extracellular matrix (ECM) in pancreatic cancer to enhance chemotherapy through sequential administration of TiO

Identifiers

PMID42421775
PMCPMC13345483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.