ArticleHemaSphere2026
Efficacy of high-frequency low-dose rituximab and acalabrutinib in chronic lymphocytic leukemia.
Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
12 authors.
Funding
Abstract
Anti-CD20 monoclonal antibodies (mAbs) are effective but not curative treatment for chronic lymphocytic leukemia (CLL). To study rituximab efficacy, we examined serial blood samples from CLL patients receiving initial monotherapy with high-frequency low-dose (HFLD) rituximab for 1 week followed by the addition of acalabrutinib. Low-dose rituximab (intravenous infusion of 25 mg over 1 h) decreased the circulating CLL cell count by 85% with no additional changes during infusion of the next 25 mg of rituximab. Limited clearance of CLL cells was not attributable to low concentrations of rituximab or complement and was most likely caused by exhaustion of innate immune cytotoxicity as previously described for larger rituximab doses. Circulating CLL counts and CD20 levels rebounded by 48 h when subcutaneous administration of 50 mg of rituximab caused a small but significant decrease in CLL cell counts. Administration of 100 mg of rituximab in the first week of therapy decreased palpable lymphadenopathy by 66%. Addition of acalabrutinib, a second-generation Bruton tyrosine kinase inhibitor (BTKi), on Day 8 of treatment was followed by decreases in CLL cell expression of
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