Evidence map›Paper›PMID 42421689›Full record

ArticleFrontiers in oncology2026

Advancing glioblastoma research by establishing a whole brain slice model.

Katharina Fuchs, Clara Keller, Bianca Layer, Katja Nadler, Ellaine Salvador, Tobias Weigel, Bastian Christ, Sofia Dembski, Ralf-Ingo Ernestus, Mario Löhr and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katharina FuchsDivision Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Clara KellerDivision Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Bianca LayerDivision Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Katja NadlerTranslational Center Regenerative Therapies TLC-RT, Fraunhofer Institute for Silicate Research ISC, Würzburg, Germany.
Ellaine SalvadorDivision Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Tobias WeigelTranslational Center Regenerative Therapies TLC-RT, Fraunhofer Institute for Silicate Research ISC, Würzburg, Germany.
Bastian ChristTranslational Center Regenerative Therapies TLC-RT, Fraunhofer Institute for Silicate Research ISC, Würzburg, Germany.
Sofia DembskiTranslational Center Regenerative Therapies TLC-RT, Fraunhofer Institute for Silicate Research ISC, Würzburg, Germany.
Ralf-Ingo ErnestusDivision Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Mario Löhr *Division Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.
Carsten Hagemann *Division Experimental Neurosurgery, Department of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organotypic brain slice cultures are well-established and valuable three-dimensional (3D) models in neuroscience, particularly for cancer research. However, many existing 3D models rely on adult animals or are restricted to specific brain regions, such as the hippocampus. To address these limitations, we established a whole, large-format brain slice model that preserves the complex cellular architecture of the brain and its diverse cell populations. In addition, the use of 6-9-day-old postnatal mice allows a reduction in animal numbers by sectioning each brain into multiple contiguous slices of 300 µm thickness. The slices were maintained

Indexed as

AlamarBlue assaybrain tumorex vivo modelingglioblastomalife-death stainingorganotypic brain slice culturesspheroids

Identifiers

PMID42421689
PMCPMC13341489

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.