ArticleFrontiers in oncology2026
TRPV1-mediated calcium signaling underlies the synergistic pro-apoptotic effects of lidocaine and melatonin in SH-SY5Y neuroblastoma cells.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lidocaine, an amide-type local anesthetic, and melatonin, a multifunctional indoleamine with mitochondrial regulatory and anticancer properties, have each been reported to modulate cancer cell survival. However, whether these agents cooperatively promote apoptosis in neuroblastoma cells through transient receptor potential vanilloid 1 (TRPV1)-mediated calcium signaling remains insufficiently defined. This study investigated the individual and combined effects of lidocaine and melatonin on SH-SY5Y human neuroblastoma cells, focusing on TRPV1-dependent intracellular mechanisms. Intracellular Ca²
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