ArticleDevelopment (Cambridge, England)2026
Ecdysone receptor autonomously controls germ cell differentiation in the Drosophila ovary.
Article in Development (Cambridge, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Germline cysts require Ecdysone receptor for proper timing of encapsulation in the Drosophila ovary.Developmental biology · 2026Article
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14 authors.
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Abstract
The steroid hormone ecdysone controls Drosophila ovarian germline stem cell (GSC) maintenance and germ cell differentiation. Prior studies demonstrated that ecdysone regulates germ cell differentiation non-autonomously via the nuclear receptor Ecdysone receptor (EcR) in ovarian somatic cells. Although EcR is also expressed in germ cells, potential direct roles for EcR in the germline independent of the soma have not been examined. Here, we demonstrate that EcR functions autonomously in GSCs and cystoblasts to control germline differentiation. While depletion of EcR from GSCs mildly reduces their maintenance, overexpression of EcR specifically in GSCs and cystoblasts impedes germ cell differentiation, phenotypically resembling loss of function of bag of marbles (bam) and bone morphogenetic protein signaling constitutive activation. We propose that EcR functions as a transcriptional repressor in GSCs and cystoblasts to suppress differentiation but becomes derepressed as the ecdysone titer increases and expression of the co-repressor Smrter decreases in dividing germ cell cysts, providing temporal control over germline differentiation. These data support the model that germ cells integrate signals from multiple cell sources that spatially and temporally control their differentiation in response to local and physiological cues.
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