Evidence map›Paper›PMID 42421596›Full record

ArticleInfluenza and other respiratory viruses2026

Evaluating Analytic Approaches to Determining Respiratory Syncytial Virus Seasonality-United States, 2014-2024.

Sophia Chkonia, Sarah Hamid, Erica Billig Rose, Amber Winn, Erin Anderson, Benjamin J Silk

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Sophia ChkoniaCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA.ORCID https://orcid.org/0000-0002-0570-8628
Sarah HamidCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA.
Erica Billig RoseCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA.ORCID https://orcid.org/0000-0001-7056-511X
Amber WinnCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA.
Erin AndersonCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA.ORCID https://orcid.org/0009-0006-1364-0025
Benjamin J SilkCoronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) is a major cause of hospitalizations among infants and older adults in the United States. Determining RSV seasonality, which varies geographically, is essential to the timely administration of prevention products. We described how a laboratory percent positivity threshold (3% threshold) performs compared to the retrospective slope 10 (RS10) and 10-fold baseline (10FB) methods in defining RSV epidemics across regions.

methodsWe analyzed RSV laboratory testing data submitted by consistent reporters to the National Respiratory and Enteric Virus Surveillance System during July 2014-June 2024. We compared the timing of epidemics, season duration, and percent of annual detections captured within the epidemic period determined from the 3% threshold, RS10, and 10FB methods.

resultsThe epidemic onset weeks determined by the 3% threshold were typically later than those identified by RS10 and varied by region when compared to 10FB. Epidemic duration was shortest with the 3% threshold and longest with RS10. RS10 captured the highest percentage of detections and varied least annually. The 3% threshold and 10FB demonstrated similar percentages of detections before the COVID-19 pandemic, but detections decreased with 10FB postpandemic.

conclusionsRS10 demonstrated high coverage of annual RSV detections and identified earlier onsets but can only be applied retrospectively. 10FB did not consistently identify season onset earlier across regions. Similar evaluation results across the three methods suggest that the 3% threshold was not impacted in determining RSV seasonality postpandemic and is a preferred US method due to its simplicity and application in near real-time.

Indexed as

Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsSeasonsEpidemicsHumansRetrospective StudiesUnited Statesrespiratory syncytial virusseasonalitysurveillance

Identifiers

PMID42421596
PMCPMC13347157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.