Evidence map›Paper›PMID 42421466›Full record

ArticleAdvanced healthcare materials2026

Targeting MAO-A With Ultrafast Kinetics: Affinity Probes for Precision Imaging of Brain Pathologies and Depression Biomarker Validation.

Lin Lei, Kun Li, Hong Zhang, Li-Na Zhang, Ding-Heng Zhou, Yan-Hong Liu, Lei Shi, Yi-Fei Tang, Xiao-Qi Yu, Kang-Kang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lin LeiKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
Kun LiKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-8788-1036
Hong ZhangDepartment of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
Li-Na ZhangKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
Ding-Heng ZhouKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
Yan-Hong LiuKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.
Lei ShiState Key Laboratory of Oral Diseases & National Clinical Research Center For Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Yi-Fei TangKey Laboratory of Bio-resources and Eco-environment, College of Life Sciences, Ministry of Education, Sichuan University, Chengdu, China.
Xiao-Qi YuDepartment of Chemistry, Xihua University, Chengdu, China.
Kang-Kang YuKey Laboratory of Bio-resources and Eco-environment, College of Life Sciences, Ministry of Education, Sichuan University, Chengdu, China.

Funding

Dedicated Postdoctoral Research and Development Fund Project of Sichuan University 2022SCU12102National Natural Science Foundation of China 22107078
6 · The paper itself

Abstract

Major depressive disorder (MDD) lacks objective biomarkers, hindering diagnosis. Monoamine oxidase A (MAO-A)-upregulated in depressed brains and degrading monoamine neurotransmitters-is a key pathological biomarker. To address limitations of current MAO-A probes (reliance on enzymatic reactions, > 1 h), we designed JBDs: near-infrared (λ

Indexed as

BrainMajor Depressive DisorderMonoamine OxidaseAnimalsBiomarkersCell Line, TumorGliomaHumansKineticsMiceBiomarkersMonoamine Oxidasedepressionlarge stokes shiftMAO‐ANIRultrafast

Identifiers

PMID42421466
PMCPMC13474116

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.