Evidence map›Paper›PMID 42421433›Full record

ArticleMedical education online2026

Agreement, calibration, and failure of three large language models as high-stakes multimodal ospe graders: a comparative psychometric analysis.

Shahid Akhtar Akhund, Sadia Qazi, Muhammad Atif Mazhar, Aftab Ahmed Shaikh, Eshal Atif, Adeen Shaikh, Hassan Shaibah, Mohammed Alged Elsheikh Musa, Sabiya N Qazi, Mateen A Khan and 1 more

Abstract readComparative Study
In one paragraph

Article in Medical education online, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shahid Akhtar AkhundDepartment of Medical Education and Department of Anatomy, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0000-0003-1820-1276
Sadia QaziDepartment of Anatomy, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0009-9275-8022
Muhammad Atif MazharDepartment of Anatomy, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0007-1588-3909
Aftab Ahmed ShaikhDepartment of Anatomy, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0009-4236-5933
Eshal AtifCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0006-7010-6910
Adeen ShaikhCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0009-7497-8662
Hassan ShaibahDepartment of Anatomy, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0000-0002-3575-6460
Mohammed Alged Elsheikh MusaDepartment of Anatomy, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0005-9890-5469
Sabiya N QaziDepartment of Life Sciences, College of Science and General Studies, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0009-0004-4054-7809
Mateen A KhanDepartment of Life Sciences, College of Science and General Studies, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0000-0002-2300-4595
Akef ObeidatDepartment of Anatomy, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.ORCID 0000-0002-4666-5118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMedical education faces increasing demand for scalable grading solutions. Large language models have been proposed as automated graders for high-stakes assessments, but evidence for their reliability in multimodal practical examinations remains limited.

methodsThis retrospective inter-rater reliability study compared three LLMs: ChatGPT-4o, Gemini 2.5 Flash, and Claude 3.5 Haiku with original human reference scores on 19 integrated anatomy, histology, and physiology objective structured practical examination items completed by 309 pre-medical students. Human reference scores were assigned during live summative grading by two content experts who divided items, with each item marked by one expert across all students; no human inter-rater reliability estimate was available. Items required simultaneous image interpretation and short-answer responses. Models were evaluated using zero-shot prompting reflecting deployment-realistic conditions. Agreement was assessed using Spearman's

resultsRank-order correlations were strong across all models (

conclusionsStrong rank-order correlation alone does not support LLM grading for categorical decisions in high-stakes assessment contexts. LLMs may serve as assessment assistants for first-pass ranking and discrepancy flagging, but item-level human review of flagged discordances, error-profile monitoring, and preserved human authority over pass/fail decisions are required before high-stakes deployment.

Indexed as

Educational MeasurementEducation, Medical, UndergraduateLarge Language ModelsCalibrationHumansObserver VariationPsychometricsReproducibility of ResultsRetrospective Studiesautomated gradinginter- responsible AILarge language modelsmultimodal assessmentOSPE

Identifiers

PMID42421433
PMCPMC13353441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.