Evidence map›Paper›PMID 42421431›Full record

GuidelineHistopathology2026

A novel classification of testicular sex cord-stromal tumours from the Testicular Sex Cord-Stromal Tumour (TESST) group: a collaboration of the Genitourinary Pathology Society (GUPS) and the International Society of Urological Pathology (ISUP).

Andres M Acosta, Felix Bremmer, John C Cheville, Maurizio Colecchia, Eva Comperat, Kristine Cornejo, Dilek E Baydar, Anthony J Gill, Maria Del Pilar Gonzalez-Peramato, Sounak Gupta and 20 more

Abstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Andres M AcostaDepartment of Pathology, Indiana University, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0001-8817-6331
Felix BremmerInstitute of Pathology, University Medical Center Göttingen, Göttingen, Germany.
John C ChevilleDepartment of Pathology, Mayo Clinic, Rochester, MN, USA.
Maurizio ColecchiaDepartment of Pathology, Universita Vita Salute San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0003-1914-0743
Eva ComperatDepartment of Pathology, Medical University Vienna, Vienna, Austria.
Kristine CornejoDepartment of Pathology, Indiana University, Indianapolis, IN, USA.
Dilek E BaydarDepartment of Pathology, Koc University School of Medicine, Istanbul, Turkey.
Anthony J GillDepartment of Pathology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Maria Del Pilar Gonzalez-PeramatoDepartment of Pathology, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain.
Sounak GuptaDepartment of Pathology, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0001-5163-6955
Michelle S HirschDepartment of Pathology, MassGeneralBrigham/Harvard Medical School, Boston, MA, USA.
Muhammad T IdreesDepartment of Pathology, Indiana University, Indianapolis, IN, USA.
Chia-Sui KaoDepartment of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH, USA.
Fiona MacLeanDepartment of Pathology, Douglass Hanly Moir Pathology, Sonic Healthcare, Sydney, NSW, Australia.
Andres MatosoDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-0990-1115
Rohit MehraDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Santosh MenonDepartment of Pathology, Tata Memorial Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-4140-0671
Kvetoslava MichalovaDepartment of Pathology, Charles University, Faculty of Medicine in Plzen, Biopticka Laborator, Ltd, Plzen, Czech Republic.ORCID https://orcid.org/0000-0003-3231-6870
Sambit K MohantyDepartment of Pathology, CORE Diagnostics, Gurgaon, Haryana, India.
Miguel Reyes-MugicaDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID https://orcid.org/0000-0001-5698-3702
Maria Rosaria RaspolliniHistopathology and Molecular Diagnostics, University Hospital Careggi and University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0001-6630-4881
Ankur R SangoiDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID https://orcid.org/0009-0007-7233-2361
Lynette M ShollDepartment of Pathology, MassGeneralBrigham/Harvard Medical School, Boston, MA, USA.
Stephanie SiegmundDepartment of Pathology, MassGeneralBrigham/Harvard Medical School, Boston, MA, USA.
Satish K TickooDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Toyonori TsuzukiDepartment of Surgical Pathology, Aichi Medical University, Nagakute, Japan.ORCID https://orcid.org/0000-0002-4855-4366
Thomas M UlbrightDepartment of Pathology, Indiana University, Indianapolis, IN, USA.
Sean R WilliamsonDepartment of Pathology and Laboratory Medicine, Diagnostics Institute, Cleveland Clinic, Cleveland, OH, USA.
Asli YilmazDepartment of Diagnostic and Molecular Pathology, Alberta Precision Labs and University of Calgary, Calgary, AB, Canada.
Daniel M BerneyCentre of Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute, Charterhouse Square, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0001-5474-8696

Funding

Genitourinary Pathology Society (GUPS)International Society of Urological Pathology (ISUP)
6 · The paper itself

Abstract

aimsTesticular sex cord-stromal tumours (TSCSTs) are rare neoplasms that arise from (or show differentiation to) elements derived from the sex cords or intertubular stroma. The current classification (World Health Organization, 2022) is based almost entirely on morphology, with many tumour types such as granulosa cell tumours being defined based on their resemblance to ovarian counterparts. Recent studies have uncovered new clinicopathological, molecular and biological nuances within this group of tumours, underscoring differences with ovarian homologues. METHODS AND

resultsConsidering the new data, a group of genitourinary pathology experts (Testicular Sex Cord-Stromal Tumour [TESST] group) has proposed a revised 'TESST classification' that incorporates the best available evidence. This classification is structured and hierarchical, composed of the following tiers: (1) group, (2) category, (3) entity and (4) histological pattern. 'Group' refers to the histological compartment a specific tumour belongs to (sex cords, stroma or both), whereas 'category' is defined by the phenotype of the tumour, taking non-neoplastic elements of the ovary and testis as a reference. The third tier, 'entity', refers to neoplasms with shared clinicopathological and/or molecular features that justify classifying them as distinct types. Lastly, 'histological patterns' are recurrent morphological variations within entities that are not linked to distinct clinicopathological or molecular features.

conclusionsWe propose a classification that will provide a framework to improve current clinical management and guide future research in the field.

Indexed as

Sex Cord-Gonadal Stromal TumorsTesticular NeoplasmsHumansMaleclassificationgranulosa cell tumourLeydig cell tumourSertoli cell tumoursex cord‐stromal tumourtestis

Identifiers

PMID42421431
PMCPMC13551126

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