ArticleJournal of clinical neurology (Seoul, Korea)2026
Neural Correlates of Intellectual Dysfunction in Episodic Ataxia Type 2.
Article in Journal of clinical neurology (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeEpisodic ataxia type 2 (EA2) is characterized by episodes of vertigo and ataxia due to mutations in
methodsWe recruited 12 patients with EA2 (including 6 males; age=30.5±14.3 years, mean±standard deviation) in 3 university hospitals of South Korea from 2019 to 2023. Regional brain volumes were quantified using voxel-based morphometry and the brainstem-structures feature of FreeSurfer. The results were compared with those for healthy controls. The relationships between regional gray-matter volumes (GMVs) and cognitive function were assessed using voxel-wise multiple regression analyses within the general linear model framework.
resultsBrain volumetry revealed a significant decrease in cerebellar volumes, particularly in the vermis (lobules IV, V, and VIII), bilateral flocculi (lobule X), and brainstem. The Full-Scale Intelligence Quotient was positively correlated with the GMVs in the left parahippocampal gyrus, right caudate nucleus, and right cerebellar crus II; the Verbal Comprehension Index was correlated with the GMVs in the bilateral cerebellar crura I and II; and the Processing Speed Index was correlated with the GMV in the right parahippocampal gyrus.
conclusionsVolumetric analyses revealed brain atrophy in patients with EA2 that was correlated with the clinical features observed in this disorder. These findings may further expand the imaging spectrum of disorders associated with
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