Evidence map›Paper›PMID 42421329›Full record

ArticlePalliative & supportive care2026

Potentially burdensome end-of-life care for colorectal cancer decedents: A retrospective cohort study.

Gifty Varghese, Tolesa Okuba, Geoffrey Delaney, Gaston Arnolda, Winston Liauw, Reidar Lystad, Reema Harrison, Jeffrey Braithwaite, Rebecca Mitchell

Abstract read
In one paragraph

Article in Palliative & supportive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gifty VargheseAustralian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie Universityhttps://ror.org/01sf06y89, Sydney, Australia.ORCID https://orcid.org/0009-0005-1055-3666
Tolesa OkubaAustralian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie Universityhttps://ror.org/01sf06y89, Sydney, Australia.
Geoffrey DelaneySydney Partnership for Health Education Research and Enterprisehttps://ror.org/0384j8v12, Australia.
Gaston ArnoldaAustralian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie Universityhttps://ror.org/01sf06y89, Sydney, Australia.
Winston LiauwUniversity of New South Wales School of Clinical Medicinehttps://ror.org/03r8z3t63, Australia.
Reidar LystadAustralian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie Universityhttps://ror.org/01sf06y89, Sydney, Australia.
Reema HarrisonAustralian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie Universityhttps://ror.org/01sf06y89, Sydney, Australia.
Jeffrey BraithwaiteAustralian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie Universityhttps://ror.org/01sf06y89, Sydney, Australia.
Rebecca MitchellAustralian Institute of Health Innovation, Faculty of Medicine, Health and Human Sciences, Macquarie Universityhttps://ror.org/01sf06y89, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesColorectal cancer is a leading cause of cancer mortality in Australia, with many patients requiring complex end-of-life care. Evidence of potentially burdensome end-of-life care specific to colorectal cancer populations in hospital settings is limited. This study aimed to examine factors associated with indicators of potentially burdensome end-of-life care among people who died from colorectal cancer and received hospital-based care in New South Wales, Australia.

methodsA retrospective population-based cohort study was conducted using linked data from the NSW Cancer Registry, hospital, and mortality records (2014-2019). Adults aged ≥20 years whose underlying cause of death was colorectal cancer and who were hospitalized in their final year of life were included. Multivariable logistic regression models examined associations between patient demographics and all indicators. Multinominal logistic regression examined predictors of a composite indicator comprising 4 indicators of potentially burdensome end-of-life care.

resultsOf 9,476 colorectal cancer decedents, 15.7% died in acute care. Within the last 30 days of life, 13.1% had >1 emergency department presentation, 9.2% had >1 hospital admission, and 3.1% had an intensive care unit admission. The composite indicator identified 71.3% of patients with no indicators, 18.9% with 1, and 9.8% with ≥2 indicators of potentially burdensome end-of-life care. Higher odds of potentially burdensome end-of-life care were observed among people who smoke, people living in rural locations, who had a lower socioeconomic status, a prior cancer diagnosis, or their final admission was to a private hospital. Females, people with comorbidities, and people who had a longer survival duration, had lower odds of potentially burdensome end-of-life care. SIGNIFICANCE OF

resultsFindings highlight socioeconomic and system-level disparities that may inform policy and clinical strategies to improve equitable, patient-centered end-of-life care.

Indexed as

Colorectal NeoplasmsTerminal CareAdultAgedAged, 80 and overCohort StudiesFemaleHumansLogistic ModelsMaleMiddle AgedNew South WalesRetrospective StudiesColorectal cancerend-of-life carehealth services researchpalliative careretrospective cohort study

Identifiers

PMID42421329
PMCPMC13370304

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.