Evidence map›Paper›PMID 42421301›Full record

ArticleMediators of inflammation2026

Clinical Application of Blood Lactate, C-Reactive Protein, and the Age-Adjusted Charlson Comorbidity Index in Predictive Assessment of Malignant Risk of MRSA Pneumonia.

Heqing Huang, Hong Lu, Yiling Chen, Qiongfang Zhu, Yalu Ren, Zutao Chen, Jie Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heqing HuangCenter of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China, sdfyy.cn.ORCID https://orcid.org/0009-0008-9627-655X
Hong LuCenter of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China, sdfyy.cn.ORCID https://orcid.org/0009-0006-2293-0024
Yiling ChenDepartment of Infectious Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China, sdfyy.cn.ORCID https://orcid.org/0009-0000-0099-6408
Qiongfang ZhuCenter of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China, sdfyy.cn.ORCID https://orcid.org/0009-0007-5151-4932
Yalu RenCenter of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China, sdfyy.cn.ORCID https://orcid.org/0009-0002-9640-9523
Zutao ChenDepartment of Infectious Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China, sdfyy.cn.ORCID https://orcid.org/0009-0001-1488-1924
Jie XuCenter of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China, sdfyy.cn.ORCID https://orcid.org/0009-0008-1134-0103

Funding

Basic Research Special Project Foundation of Suzhou SSD2024085Pfizer Foundation 76080151
6 · The paper itself

Abstract

backgroundThe objective of this study is to develop an early warning model that combines the age-adjusted Charlson comorbidity index (aCCI) with serum lactate (Lac) and C-reactive protein (CRP) levels to predict the progression of early methicillin-resistant Staphylococcus aureus (MRSA) pneumonia into severe pneumonia (SP).

methodsThis study was a retrospective case-control analysis. Sixty-four inpatients diagnosed with MRSA pneumonia at the First Affiliated Hospital of Soochow University from November 2023 to August 2024 were selected as study subjects. They were divided into two groups: the SP group (SP group) and the non-SP (nSP) group, based on established diagnostic criteria for SP. Demographic, clinical, and laboratory data of the patients were collected and statistically analyzed.

resultsTwenty-four patients (37.5%) developed SP, and the aCCI score was significantly higher in the SP group compared to the nSP group, with a statistically significant difference between the two groups (p  < 0.05). Hospital-associated pneumonia caused by hospital-acquired MRSA (HA-MRSA) was more prevalent in the nSP group (p  < 0.05). However, the differences between the SP and nSP groups were not statistically significant for laboratory indicators such as white blood cell (WBC) count, lymphocyte (LY) count, neutrophil (NE) count, and platelet (PLT) count (p  > 0.05). The levels of CRP and serum Lac in the SP group were significantly higher than those in the nSP group, with statistically significant differences (p  < 0.05). Multifactorial logistic regression analysis indicated that HA-MRSA was an independent protective factor against MRSA-associated SP, while the aCCI score, CRP, and serum Lac levels were identified as risk factors for the progression of MRSA to SP. The combination of these three factors demonstrated good predictive efficacy, with an area under the curve (AUC) of 0.913 (p  < 0.001, 95% CI: 0.841, 0.985).

conclusionMRSA strains associated with SP demonstrate a lack of specificity in their clinical manifestations. HA-MRSA is less likely to lead to SP compared to community-acquired MRSA (CA-MRSA). An aCCI score ≥7, in conjunction with elevated levels of early CRP and serum Lac, can serve as effective early indicators that MRSA pneumonia may progress to a severe form.

Indexed as

C-Reactive ProteinLactic AcidMethicillin-Resistant Staphylococcus aureusPneumonia, StaphylococcalAgedCase-Control StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsC-Reactive ProteinLactic AcidaCCI scoreblood lactateCRPearly warning modelMRSAsevere pneumonia

Identifiers

PMID42421301
PMCPMC13346585

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.