Evidence map›Paper›PMID 42421284›Full record

ArticleJACC. Case reports2026

Transcatheter Mitral Valve-in-Valve Replacement With Microaxial Flow-Pump Support for Bioprosthetic Valve Failure.

Daniel Schwarzkopf, Hristian Hinkov, Anika Nagel, Chong Bin Lee, Christoph Klein, Marian Kukucka, Evgenij Potapov, Axel Unbehaun

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel SchwarzkopfStructural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany. Electronic address: daniel.schwarzkopf@dhzc-charite.de.
Hristian HinkovStructural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Anika NagelCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany.
Chong Bin LeeStructural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Internal Medicine and Cardiology, Berlin, Germany.
Christoph KleinStructural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Internal Medicine and Cardiology, Berlin, Germany.
Marian KukuckaStructural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiac Anaesthesiology and Intensive Care Medicine, Berlin, Germany.
Evgenij PotapovCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Axel UnbehaunStructural Heart Interventions Program (SHIP), Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Deutsches Herzzentrum der Charité (DHZC), Department of Cardiothoracic and Vascular Surgery, Berlin, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStructural deterioration of bioprosthetic mitral valves is a common cause of late valve failure, requiring surgical or transcatheter replacement of the failed prosthesis. In rare cases, hemodynamic compromise may lead to cardiogenic shock, requiring mechanical circulatory support and making treatment particularly challenging. CASE SUMMARY: A 76-year-old man with prior bioprosthetic mitral valve replacement presented with cardiogenic shock. A microaxial flow pump was implanted. Echocardiography revealed severe transvalvular mitral regurgitation due to leaflet tear. Because of prohibitive surgical risk, the heart team opted for transcatheter mitral valve-in-valve replacement. The procedure resulted in immediate hemodynamic stabilization and weaning from mechanical support within 24 hours. DISCUSSION: This case demonstrates the feasibility of transcatheter mitral valve replacement combined with microaxial flow-pump support in cardiogenic shock as a potential rescue therapy in selected patients. TAKE-HOME MESSAGE: Timely transcatheter intervention may be life-saving in cardiogenic shock due to bioprosthetic mitral valve failure.

Indexed as

acute heart failureinotropesinsufficiencymitral valvevalve replacement

Identifiers

PMID42421284
PMCPMC13531072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.