ArticleJACC. Case reports2026
Secondary Giant Cardiac Lymphoma Treated by Stepwise Chemotherapy With Multimodal Imaging.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMetastatic cardiac lymphoma is rare and may present as a large mass with a high risk of hemodynamic compromise and poor outcomes. CASE SUMMARY: A 79-year-old woman who had a history of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma and achieved remission after radiotherapy presented with dyspnea and edema. Transthoracic echocardiography and computed tomography revealed a large mass occupying the right atrium and ventricle. Biopsy confirmed diffuse large B-cell lymphoma, suggesting a late transformation of MALT lymphoma with cardiac involvement. Low-dose chemotherapy was initiated and gradually escalated with multimodal imaging guidance, resulting in marked mass regression without complications. DISCUSSION: Transformation of MALT lymphoma into diffuse large B-cell lymphoma can occur after long-term remission and present as isolated cardiac involvement. Stepwise chemotherapy may help reduce the risk of embolic events and cardiac rupture. TAKE-HOME MESSAGE: Serial multimodal imaging plays a pivotal role in monitoring the response to chemotherapy in patients with cardiac lymphoma.
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