ArticleRadiation oncology (London, England)2026
Multi-regional radiomics based on planning CT and information complementarity between GTVp and GTVn: an explainable model for predicting 5-year recurrence risk in HPV-positive oropharyngeal cancer.
Article in Radiation oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aims to develop and validate a multi-regional radiomics machine learning model integrating the spatial heterogeneity features of both the primary gross tumor volume (GTVp) and metastatic lymph nodes (GTVn) to explore its potential as a non-invasive tool for estimating the 5-year recurrence risk of HPV-positive oropharyngeal carcinoma (OPC) patients.
methodsThis study included 716 HPV + OPC patients from three independent datasets (training set: 390; internal validation set: 166; independent test set: 160). PyRadiomics was used to extract radiomic features from each target volume. Ten classical machine learning models were constructed, and the SHAP algorithm was applied to quantify feature contributions and optimize core variables. A clinical-radiomics model based solely on GTVp and a clinical-radiomics model based on a feature-level fusion strategy (GTVp&n) were established respectively.
resultsThe XGBoost model based on the GTVp&n strategy showed the best performance, with AUCs of 0.907, 0.852, and 0.835 in the training, internal validation, and independent test set, respectively-significantly higher than those of the single GTVp model and the GTVpn (fused target volume) model. A nomogram incorporating clinical factors demonstrated good discrimination, calibration, and clinical utility across all datasets. NRI (0.242) and IDI (0.097) analyses confirmed that this combined model significantly improved risk reclassification capability compared to the GTVp-based clinical-radiomics model.
conclusionA multi-regional radiomics model integrating features from both the primary lesion and cervical lymph nodes significantly enhances the predictive performance for recurrence risk in HPV + OPC. This model facilitates individualized recurrence risk stratification and may generate research hypotheses for future exploration of personalized de-escalation or intensified treatment strategies, as well as supporting individualized follow-up management.
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