ArticleJournal of medical case reports2026
Nasopharyngeal classical Hodgkin lymphoma: a case report.
Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHodgkin lymphoma is a malignant lymphoid neoplasm that most commonly originates in lymph nodes, particularly within the cervical, mediastinal, and axillary regions. Extranodal involvement is relatively uncommon, and primary nasopharyngeal Hodgkin lymphoma defines a rare clinical phenomenon. Diagnosis may be delayed because its clinical presentation resembles more common nasopharyngeal conditions. CASE PRESENTATION: A 51-year-old Palestinian woman presented with progressive nasal obstruction and snoring. Endoscopic examination revealed a mass in the nasopharynx. Histopathological analysis confirmed lymphocyte-rich classical Hodgkin lymphoma, staged as IIA. The patient was treated with four cycles of ABVD chemotherapy followed by involved-site radiotherapy using CT simulation with a total dose of 30.6 Gy delivered in 17 fractions, resulting in complete resolution of the lesion. At 12 months of follow-up, the patient remained disease-free with full clinical recovery.
conclusionThis case highlights the diagnostic challenges posed by rare extranodal presentations of Hodgkin lymphoma and illustrates the value of maintaining a broad differential diagnosis and performing timely histopathological evaluation in patients with persistent nasal symptoms.
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