ArticleInfectious agents and cancer2026
Diverse non-vaccine high-risk HPV genotypes in rural Kerala: implications for cervical cancer prevention in an underserved population.
Article in Infectious agents and cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe distribution of high-risk human papillomavirus (hrHPV) genotypes varies across populations and directly influences cervical cancer prevention strategies. Data from underserved rural populations remain limited.
methodsA community-based screening study was conducted among 358 women from rural and tribal regions of Kerala, India. High-risk HPV was detected using real-time PCR, and non-16/18 genotypes were identified through L1 gene sequencing and phylogenetic analysis.
resultsThe prevalence of hrHPV infection was 2.23% (8/358). Detected genotypes included HPV16, HPV31, HPV35, HPV45, HPV66, and HPV70. All detected infections were due to high-risk HPV genotypes, of which three were non-vaccine high-risk types. Phylogenetic analysis demonstrated close similarity with globally circulating strains.
conclusionsDespite low prevalence, the presence of diverse non-vaccine hrHPV genotypes highlights a potential gap between circulating strains and current vaccine coverage. These findings highlight the importance of continued region-specific HPV surveillance in underserved populations and provide baseline epidemiological data for future studies evaluating cervical cancer prevention strategies.
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