Evidence map›Paper›PMID 42421014›Full record

ArticleMicrobial cell factories2026

Metabolic engineering of Synechocystis sp. PCC 6803 for olivetolic acid production.

E-Bin Gao, Wenrui Ji, Yangjie Zhu, Junhua Wu

Abstract read
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In one paragraph

Article in Microbial cell factories, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

E-Bin GaoSchool of Biological Science and Technology, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China.
Wenrui JiSchool of Biological Science and Technology, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China.
Yangjie ZhuSchool of Biological Science and Technology, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China.
Junhua WuDepartment of Pediatric, The affiliated Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China. wudata@163.com.

Funding

National Natural Science Foundation of China 31200019Ningbo Clinical Research Center for Children's Health and Diseases 2019A21002Ningbo Leading Medical &Health Discipline No.2026-A34Ningbo Municipal Bureau of Science and Technology Project No.2025Z153Ningbo Top Medical and Health Research Program No. 2022020405Open Fund of Key Laboratory of Tropical Marine Bio-resources and Ecology, Chinese Academy of Sciences LMB131001
6 · The paper itself

Abstract

Olivetolic acid (OLA), the critical aromatic precursor for plant-derived cannabinoids, conventionally relies on resource-intensive plant extraction or complex chemical synthesis. This study establishes an environmentally friendly biosynthetic platform by genetically engineering the model cyanobacterium Synechocystis sp. PCC 6803. We constructed the heterologous OLA pathway by co-expressing plant-derived tetraketide synthase (TKS), olivetolic acid cyclase (OAC), and acyl-activating enzyme 1 (AAE1). Through cultivation supplemented with sodium hexanoate, successful biosynthesis of OLA was achieved within this photosynthetic host. To overcome metabolic bottlenecks, the pathway was further optimized using the robust P

Indexed as

Metabolic EngineeringSynechocystisPromoter Regions, GeneticCO2 fixationMetabolic engineeringOlivetolic acidSynechocystis sp. PCC 6803

Identifiers

PMID42421014
PMCPMC13628793

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.