Evidence map›Paper›PMID 42420978›Full record

ArticleRespiratory research2026

Airway wall thickness and PRISm are associated with cognitive impairment in individuals with cigarette smoking exposure.

Karin F Hoth, Carinda Linkenmeyer, Gregory L Kinney, John D Newell, Elizabeth A Regan, Barry Make, Katherine A Pratte, Alejandro P Comellas, Eric A Hoffman, Spyridon Fortis and 11 more

Abstract read
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In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Karin F HothDepartment of Psychiatry, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA. karin-hoth@uiowa.edu.ORCID http://orcid.org/0000-0002-4261-5308
Carinda LinkenmeyerDepartment of Psychiatry, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.
Gregory L KinneyDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
John D NewellDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Elizabeth A ReganDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Barry MakeDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Katherine A PratteDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO, USA.
Alejandro P ComellasDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Eric A HoffmanDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Spyridon FortisDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Jess G FiedorowiczUniversity of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abebaw M YohannesDepartment of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
Anand S IyerDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Marilyn G ForemanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Ken M KunisakiSection of Pulmonary, Allergy, Critical Care and Sleep Medicine, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
Sharon M LutzDepartment of Biostatistics, T.H. Chan School of Public Health, Boston, MA, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
James D CrapoDepartment of Medicine, National Jewish Health, Denver, CO, USA.
Erin AustinDepartment of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
GENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Determinants of Altered Brain Structure and Function in Smokers with COPD-Related Lung PathophysiologyR01HL134822 · NHLBI · UNIVERSITY OF IOWA · PI HOTH, KARIN F · 2017 to 2021
$3.1M
The role of sex in genetic association studies of depressionR01MH129337 · NIMH · HARVARD PILGRIM HEALTH CARE, INC. · PI Sharon Marie Lutz · 2022 to 2026
$2.1M
NHLBI NIH HHS 75N92023D00011NHLBI NIH HHS R01 HL134822NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIH U01HL089897, U01HL089856, 75N92023D00011NIH HHS R01 HL134822NIH HHS R01MH129337NIH HHS U01HL089897, U01HL089856, 75N92023D00011NIMH NIH HHS R01 MH129337NIMH NIH HHS R01MH129337
6 · The paper itself

Abstract

backgroundIndividuals with chronic obstructive pulmonary disease (COPD) and cigarette smoking exposure are at increased risk of cognitive impairment; however, the clinical characteristics of those at risk are incompletely understood.

methodsWe conducted a secondary analysis of COPDGene cohort data to identify clinical characteristics, particularly pulmonary function and lung CT metrics, associated with cognitive impairment. Cognitive items available from Phase 3 included: self-report of a cognitive disorder diagnosis and cognitive difficulties, and probable cognitive impairment (pCI) defined by Mini-Cog ≤ 3. Thirty-seven variables were considered for inclusion in a mixed effects logistic regression with pCI as the dependent variable including demographics, smoking history, medical history, symptom severity, pulmonary function testing, and COPD-related lung CT variables.

resultsAmong 2,079 participants (mean age = 68.7[SD ± 8.6] years, 51.2% female, 28.7% African American), the frequency of pCI differed by smoking/COPD severity group (9.4% never smokers, 18.7% smoking history-normal spirometry, 30.0% preserved ratio impaired spirometry [PRISm], 26.3% GOLD 1-4; p < 0.001). Older age, male sex, lower education, African American race, lower body mass index, higher anxiety symptoms, and CT metrics (higher Perc15 and Pi10) were associated with pCI in the final model.

conclusionsJust under thirty percent of participants with smoking exposure and evidence of lung disease on spirometry (PRISm or GOLD 1-4) had pCI, with the highest frequency in PRISm and advanced COPD. Several demographic and clinical characteristics were associated with pCI including airway disease measured via Pi10 on lung CT pointing to a potential link between specific COPD-related physiology and cognitive impairment.

Indexed as

Cigarette SmokingCognitive DysfunctionPulmonary Disease, Chronic ObstructiveSpirometryAgedCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsTomography, X-Ray ComputedAirway wall thicknessCigarette smokingCognitionMini-Cog

Identifiers

PMID42420978
PMCPMC13663183

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.