ArticleMethods in molecular biology (Clifton, N.J.)2026
Quantitative Coarse-Grained Modeling of Microbial Metabolism: Uncovering Growth Laws, Environmental Responses, and Host-Circuit Coupling.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Microbial cell metabolism is highly complex, involving a vast number of molecular species and multi-level regulatory processes. To address this complexity and decode cellular behavior, coarse-grained modeling provides a powerful quantitative framework by grouping similar biological entities while preserving essential network properties. This approach offers insights into intracellular regulation and resource allocation, enables systematic analysis of natural biological systems, and generates predictions for synthetic engineering outcomes. In this chapter, we present a comprehensive overview of coarse-grained modeling, from model construction to applications, and demonstrate its utility in uncovering microbial metabolic behavior.
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