Evidence map›Paper›PMID 42420703›Full record

ReviewAdvances in experimental medicine and biology2026

Glycosaminoglycans and Their Role in Capillary Walls.

Lorna K Milne, Kenton P Arkill

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lorna K Milne *Nottingham GlycoAnalytics Hub, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
Kenton P Arkill *Nottingham GlycoAnalytics Hub, Biodiscovery Institute, University of Nottingham, Nottingham, UK. Kenton.arkill@nottingham.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycosaminoglycans (GAGs) are polysaccharide chains that extend into the vascular lumen and are embedded throughout the capillary wall. They have a multitude of biophysical and biochemical roles including control of vascular permeability, shear stress detection and growth factor uptake. The spatial distribution of GAGs is key to their function and, when coupled to their post-transcriptional synthesis, becomes technically challenging to analyse in model systems. This chapter brings together the evidence for their role in capillary permeability using the glomerular filtration barrier as an example. We also discuss methods, and potential methods, of in situ capillary scale imaging and analysis.

Indexed as

CapillariesCapillary PermeabilityGlomerular Filtration BarrierGlycosaminoglycansAnimalsGlycocalyxHumansGlycosaminoglycansEndothelial glycocalyxGlomerular filtration barrierProteoglycanSecondary ion mass spectrometryVascular permeability

Identifiers

PMID42420703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.