ArticleNature2026
Aneuploidy selects for the acquisition of driver genes in breast cancer.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors.
Khalid N Al-ZahraniCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. khalid.alzahrani@utoronto.ca.ORCID http://orcid.org/0000-0001-5771-7537
Ellen R LangilleCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Jocelyn NurtantoCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Andreea ObersterescuCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3285-0221
Katie TengCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-7459-4193
Christopher LowdenCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1839-164X
Julien DessaptCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5748-3320
Cynthia H ChiuCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Lauren V CaldwellCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-9991-0757
David P CookCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Miguel A Pérez-CastroCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2850-3470
Jacob M BermanCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Ricky TsaiCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5916-6978
Alexander T BahcheliDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6095-0233
Geraldine MbamaluCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Shifei WuCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-9158-9695
Masahiro NarimatsuCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5381-1972
Adele G LopesCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0007-1366-5553
Iosifina FotiadouCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Kin ChanCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Linkang ZhangCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
K W Annie BangCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0000-5506-0543
Michael J ParsonsCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Larissa MouraoDepartment of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8046-5366
E Idil TemelDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0124-3840
Liddy McCullaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Palavalasa SravyaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8556-7481
Costas A LyssiotisRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Alexander D BorowskyDepartment of Pathology, UCSF School of Medicine, San Francisco, CA, USA.
Colinda L G J ScheeleDepartment of Oncology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8999-5451
Daniel R WahlDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9894-5085
Hartland W JacksonCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-6423-2415
Katherine S StewartCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3227-982X
Elaine FuchsHoward Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0978-5137
Sean E EganDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0189-3202
Miguel Angel PujanaProgram Against Cancer Therapeutic Resistance, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, L'Hospitalet del Llobregat, Barcelona, Spain.ORCID http://orcid.org/0000-0003-3222-4044
Jüri ReimandDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-2299-2309
Jeffrey L WranaCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0932-0644
Daniel SchramekCentre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. schramek@lunenfeld.ca.ORCID http://orcid.org/0000-0001-9977-2104
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome instability is highly prevalent in cancer and drives large-scale chromosomal imbalances, known as aneuploidies
Indexed as
AneuploidyBreast NeoplasmsGenes, NeoplasmOncogenesAnimalsCRISPR-Cas SystemsDisease Models, AnimalDNA Copy Number VariationsFemaleHumansMiceMitochondriaReactive Oxygen SpeciesSignal TransductionTumor Suppressor Protein p53Reactive Oxygen SpeciesTumor Suppressor Protein p53
Identifiers
PMID
42420452What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.