Evidence map›Paper›PMID 42420447›Full record

ArticleNature2026

An intrinsic cytoskeletal oscillator establishes neuronal polarity.

Tien-Chen Lin, Charlotte H Coles, Eissa Alfadil, Florian Fäßler, Andreas Husch, Sebastian Dupraz, Thorben Pietralla, Akihiro Narita, Max Schelski, Kevin C Flynn and 7 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tien-Chen LinLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Charlotte H ColesLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Eissa AlfadilLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Florian FäßlerInstitute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.ORCID http://orcid.org/0000-0001-7149-769X
Andreas HuschLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Sebastian DuprazLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Thorben PietrallaLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Akihiro NaritaDivision of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
Max SchelskiLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Kevin C FlynnLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Sina SternLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Christoph MöhlImage and Data Analysis Facility, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Brett J HiltonInternational Collaboration on Repair Discoveries (ICORD), Djavad Mowafaghian Centre for Brain Health, and Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-2813-2294
Franz VautiDepartment of Cellular and Molecular Neurobiology, Technische Universität Braunschweig, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-0275-1433
Hans-Henning ArnoldDepartment of Cellular and Molecular Neurobiology, Technische Universität Braunschweig, Braunschweig, Germany.
Florian K M SchurInstitute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.ORCID http://orcid.org/0000-0003-4790-8078
Frank BradkeLaboratory for Axon Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. frank.bradke@dzne.de.ORCID http://orcid.org/0000-0002-0345-3772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurons acquire polarity by specifying one neurite as the axon, whereas the others become dendrites. But how this fundamental asymmetry is established remains unclear

Indexed as

Cell PolarityCytoskeletonNeuronsActin-Related Protein 2-3 ComplexActinsActomyosinAnimalsAxonsCells, CulturedDendritesGrowth ConesMiceMicrotubulesNeuritesOptogeneticsActin-Related Protein 2-3 ComplexActinsActomyosin

Identifiers

PMID42420447
PMCPMC13538037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.