Evidence map›Paper›PMID 42420446›Full record

ArticleNature2026

Non-genotoxic transplantation and in vivo selection through epitope editing.

Gabriele Casirati, Andrea Cosentino, Marta Freschi, Jing Zeng, Adele Mucci, Sébastien Levesque, Nola Neri, Enrico Drago, Viola Carzaniga, Francesco Romano and 11 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Gabriele Casirati *Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1925-1195
Andrea Cosentino *Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Marta FreschiDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0009-0378-6655
Jing ZengDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Adele MucciDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1532-4414
Sébastien LevesqueDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Nola NeriDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Enrico DragoDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Viola CarzanigaDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Francesco RomanoDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3829-3139
Varun KattaDepartment of Hematology, St Jude's Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-4565-7335
Azusa MatsubaraDepartment of Hematology, St Jude's Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0007-1637-6386
Yichao LiDepartment of Hematology, St Jude's Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-5791-096X
Mohammed S MahmoudDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9190-6590
Moisés Chávez-NavarroDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Christian BrendelDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
John P ManisDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.
Shengdar TsaiDepartment of Hematology, St Jude's Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-9161-3993
Danilo PellinDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2647-0508
Daniel BauerDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5076-7945
Pietro GenoveseDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. Pietro.Genovese@childrens.harvard.edu.ORCID http://orcid.org/0000-0001-9507-9003

Funding

Chemotherapy-free cure of hemoglobin disorders through base editingR01HL170629 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Daniel Evan Bauer, Pietro Genovese · 2023 to 2026
$3.1M
Multiplex Epitope Editing to Enable Novel Immunotherapies for Acute Myeloid LeukemiaR01CA286036 · NCI · BOSTON CHILDREN'S HOSPITAL · PI Pietro Genovese · 2024 to 2026
$2.2M
Development, Optimization and Preclinical Modeling of Hematopoietic Stem Cell Gene Editing for the Treatment of RAG1 ImmunodeficiencyR01AI155796 · NIAID · DANA-FARBER CANCER INST · PI GENOVESE, PIETRO · 2021 to 2025
$2.2M
NCI NIH HHS R01 CA286036NHLBI NIH HHS R01 HL170629NIAID NIH HHS R01 AI155796
6 · The paper itself

Abstract

The short-term and long-term effects of genotoxic pre-transplant conditioning remain barriers to the broader application of haematopoietic stem/progenitor cell (HSPC) transplantation and gene therapies

Indexed as

EpitopesGene EditingHematopoietic Stem Cell TransplantationAnimalsAntibodies, Monoclonalbeta-ThalassemiaFemaleHematopoiesisHematopoietic Stem CellsHumansMaleMiceProto-Oncogene Proteins c-kitAntibodies, MonoclonalEpitopesProto-Oncogene Proteins c-kit

Identifiers

PMID42420446
PMCPMC13538065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.