ArticleEvidence-based dentistry2026
Should chlorhexidine mouthwash be a concern for blood pressure in dental patients?
Article in Evidence-based dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
a commentary onToonen LSJ, et al. The Effect of Chlorhexidine Mouthwash on Blood Pressure: A Systematic Review and Meta-Analysis. Int J Dent Hyg. 2026. https://doi.org/10.1111/idh.70035 .
objectiveTo evaluate whether current clinical evidence supports an association between chlorhexidine mouthwash (CHX-MW) use and changes in blood pressure in human populations. DATA SOURCES: Evidence was derived from a systematic review and meta-analysis of studies identified through PubMed/MEDLINE and Cochrane CENTRAL up to December 2024. STUDY SELECTION: Randomised, controlled, and observational studies evaluating blood pressure following chlorhexidine mouthwash use were included.
methodsEvidence was synthesised through narrative review and meta-analysis, with methodological quality and risk of bias assessed using established appraisal frameworks.
resultsFive studies met the inclusion criteria. Although two studies reported small increases in blood pressure, the pooled analysis found no statistically or clinically significant effect of chlorhexidine mouthwash on systolic or diastolic blood pressure.
conclusionsCurrent evidence does not demonstrate a clinically meaningful effect of chlorhexidine mouthwash on blood pressure, but certainty remains low due to methodological limitations and indirectness of study populations.
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