Cryo-EM structures of naturally occurring dimeric photosystem II complexes lacking the Mn

Ziyu Zhao, Irene Vercellino, Julian P Whitelegge, Karim Maghlaoui, Wojciech Białek, Peter J Nixon, Leonid A Sazanov

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ziyu Zhao *Institute of Science and Technology Austria, Klosterneuburg, Austria.

Irene Vercellino *Institute of Science and Technology Austria, Klosterneuburg, Austria.ORCID http://orcid.org/0000-0001-5618-3449

Julian P WhiteleggePasarow Mass Spectrometry Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2763-7733

Karim MaghlaouiSir Ernst Chain Building-Wolfson Laboratories, Department of Life Sciences, Imperial College London, S. Kensington Campus, London, UK.

Wojciech BiałekSir Ernst Chain Building-Wolfson Laboratories, Department of Life Sciences, Imperial College London, S. Kensington Campus, London, UK.ORCID http://orcid.org/0000-0002-3390-5450

Peter J NixonSir Ernst Chain Building-Wolfson Laboratories, Department of Life Sciences, Imperial College London, S. Kensington Campus, London, UK. p.nixon@imperial.ac.uk.ORCID http://orcid.org/0000-0003-1952-6937

Leonid A SazanovInstitute of Science and Technology Austria, Klosterneuburg, Austria. sazanov@ist.ac.at.ORCID http://orcid.org/0000-0002-0977-7989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robust oxygenic photosynthesis requires the efficient assembly and repair of the multi-subunit oxygen-evolving photosystem II (PSII) complex. Previous cryogenic electron microscopy (cryo-EM) structures of PSII assembly/disassembly intermediates have relied on the analysis of deletion mutants or removal of PSII subunits in vitro. Here we report the cryo-EM structures of naturally occurring dimeric PSII intermediates from the cyanobacterium Thermosynechococcus vestitus at a resolution of about 2.2 Å. These intermediates contain inactive dimers lacking the oxygen-evolving complex (OEC) and semi-active dimers with the OEC present in one of the two monomers. Our structural data provide a mechanism for how assembly and disassembly of the Mn

Indexed as

ManganesePhotosystem II Protein ComplexThermosynechococcusCalciumCryoelectron MicroscopyModels, MolecularOxygenProtein MultimerizationCalciumManganeseOxygenPhotosystem II Protein Complex

Identifiers

PMID42420307

DOI10.1038/s41467-026-75324-x

PMCPMC13478394

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.