ArticleNature communications2026
Dynamic interactions between epithelial skin cells and a sensory cavity sculpt the growing olfactory orifice.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
During morphogenesis and in pathological conditions, gaps can form in the plane of epithelial barriers upon cellular forces that disrupt intercellular junctions. How the size of these epithelial holes further increases over time and what sets their shape remain poorly understood. Here we analyze the formation of the olfactory orifice (the nostril) in zebrafish, which opens and grows in the skin epithelium above a rosette of olfactory placode cells, allowing the sensory neurons to directly access odor cues. Using quantitative imaging and tissue-specific perturbations, we analyze the dynamic remodeling of skin cells allowing the expansion of the orifice edge. We identify the sensory cavity located in the center of the placodal rosette as a crucial player that sets the size of the growing epithelial hole in the skin. We further show that fine-tuning of actomyosin contractility within each tissue (skin and sensory cavity) exerts non-autonomous effects on the neighboring tissue, thereby shaping the nostril structure. This study uncovers dynamic cell behaviors and reciprocal tissue-tissue interplay that control the growth and shape of an epithelial hole in vivo.
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